Description

High-purity Hyodeoxycholic acid (HDCA), a secondary bile acid demonstrating significant therapeutic potential in colorectal cancer (CRC) and cholestatic liver fibrosis.

Technical Specifications

• Molecular Formula: C₂₄H₄₀O₄
• Molecular Weight: 392.6 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in organic solvents

IUPAC Name: (4R)-4-[(3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

InChI: InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1

InChIKey: DGABKXLVXPYZII-SIBKNCMHSA-N

Canonical SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CC(C4C3(CCC(C4)O)C)O)C

Isomeric SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H]([C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

Synonyms: HYODEOXYCHOLIC ACID; 83-49-8; Hyodesoxycholic acid; HDCA; Iodeoxycholic acid; 7-Deoxyhyocholic acid; .alpha.-Hyodeoxycholic acid; 3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid; …

Botanical Source:

Key Features & Benefits

• FXR activator
• Anti-proliferative properties
• Anti-fibrotic effects
• Low cytotoxicity profile
• Comprehensive Certificate of Analysis

Research Applications

1. Cancer Research

   • CRC proliferation inhibition
   • FXR/EREG/EGFR pathway studies
   • Cell cycle analysis
   • Colony formation studies

2. Liver Disease Research

   • Cholestatic liver fibrosis
   • Liver protection studies
   • Anti-fibrotic mechanisms
   • ETV4 expression research

Biological Activities

1. Cancer Inhibition

   • Activates FXR
   • Inhibits EREG/EGFR pathway
   • Reduces cell proliferation
   • Affects cell cycle progression

2. Liver Protection

   • Ameliorates liver fibrosis
   • Modulates m6A regulation
   • Affects ETV4 expression
   • Shows protective effects

Effective Concentrations

• CRC studies: 100-200 μM
• In vivo dosing: 75-150 mg/kg
• Demonstrated safety at these ranges
• Low cytotoxicity profile

Storage & Handling

• Store at -20°C
• Protect from light
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

This premium-grade HDCA is designed for research institutions and pharmaceutical companies advancing therapeutic development.

For research and development purposes only. Not for human consumption or clinical use.