Description

IUPAC Name: (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one

InChI: InChI=1S/C20H20O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9,18,21-23H,8,10H2,1-2H3/t18-/m0/s1

InChIKey: LPEPZZAVFJPLNZ-SFHVURJKSA-N

Canonical SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)O)C

Isomeric SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC=C(C=C3)O)C

Synonyms: 8-Prenylnaringenin; 53846-50-7; Sophoraflavanone B; Flavaprenin; (-)-8-Prenylnaringenin; (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one; (S)-8-dimethylallylnaringenin; 8-?Prenylnaringenin; …

Botanical Source: Humulus lupulus Linn.

Product Overview

High-purity 8-Prenylnaringenin (8-PN), a potent phytoestrogen isolated from Humulus lupulus (hops), manufactured to exceptional standards for endocrine and pharmaceutical research.

Technical Specifications

• Molecular Formula: C₂₀H₂₀O₅
• Molecular Weight: 340.4 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO, ethanol; poorly soluble in water

Key Features & Benefits

• Natural prenylated flavonoid
• The most potent phytoestrogen known
• Validated structure and activity
• Comprehensive Certificate of Analysis
• Full spectroscopic characterization

Research Applications

1. Endocrine Research

   • Estrogen receptor studies
   • Hormonal activity investigations
   • Menopausal research
   • Bone density studies

2. Pharmaceutical Development

   • Women’s health research
   • Metabolic pathway studies
   • Drug discovery screening
   • Bioavailability investigations

3. Mechanism Studies

   • Receptor binding assays
   • Structure-activity relationships
   • Cell signaling pathways
   • Molecular target identification

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Research Support

BIORLAB provides:

• Technical consultation
• Analytical method support
• Stability data
• Custom synthesis options
• Application Guidance

Key Research Areas

1. Hormonal Activity

   • Estrogenic effects
   • Receptor binding profiles
   • Tissue-specific responses
   • Endocrine modulation

2. Women’s Health

   • Menopausal symptoms
   • Bone health research
   • Hot flash studies
   • Metabolic effects

3. Molecular Mechanisms

   • Signal transduction
   • Gene expression
   • Protein interactions
   • Cellular responses

This premium-grade 8-Prenylnaringenin is specifically designed for research institutions and pharmaceutical companies advancing therapeutic development and scientific research.

For research and development purposes only. Not for human consumption or clinical use.

[Contact BIORLAB’s technical support team for detailed specifications and custom requirements]