Description

IUPAC Name: methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

InChI: InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1

InChIKey: OGWKCGZFUXNPDA-XQKSVPLYSA-N

Canonical SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

Isomeric SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

Synonyms: vincristine; 22-Oxovincaleukoblastine; Vinkristin; Leurocristine; Vincrystine; 57-22-7; leucristine; vincristin; …

Botanical Source: Catharanthus roseus （L.）G. Don

Product Overview

Vincristine, a naturally occurring vinca alkaloid isolated from Catharanthus roseus (Madagascar periwinkle), is a critical compound in cancer research and treatment development. BIORLAB provides research-grade Vincristine sulfate with exceptional purity (≥98%) for pharmaceutical research and development applications.

Technical Specifications

• Molecular Formula: C₄₆H₅₆N₄O₁₀
• Molecular Weight: 825 g/mol
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in water, methanol; slightly soluble in ethanol
• Optical Rotation: [α]20/D -28° to -35° (c = 0.5 in methanol)
• Purity: ≥98% (HPLC)
• pH: 3.5-5.5 (1% aqueous solution)

Key Research Applications

• Oncology Research
  • Microtubule assembly inhibition studies
  • Cell division mechanism investigation
  • Cancer cell proliferation research
• Therapeutic Development
  • Leukemia treatment research
  • Lymphoma studies
  • Combination therapy investigations

Critical Storage Requirements

• Store at -20°C under an inert atmosphere
• Protect from light and moisture
• Reconstituted solutions stable for 24 hours at 2-8°C
• Available in precise research quantities (1mg, 5mg, 10mg)
• Handle with appropriate safety measures

Quality Assurance

• Full analytical documentation
• Comprehensive Certificate of Analysis
• Batch-specific purity data
• Meets USP/EP specifications
• Stringent quality control testing

Research Significance

1. Mechanism of Action Studies

   • Tubulin binding research
   • Mitotic arrest investigations
   • Cell death pathway analysis

2. Clinical Research Applications

   • Drug resistance studies
   • Bioavailability research
   • Novel formulation development

3. Specialized Research Areas

   • Pediatric cancer research
   • Hematological malignancy studies
   • Combination therapy optimization

Why Choose BIORLAB’s Vincristine

• Highest available purity
• Complete documentation package
• Expert technical consultation
• Validated analytical methods
• Research-optimized packaging
• Specialized handling protocols

Research Focus Areas

• Cancer Biology

  • Cell cycle regulation
  • Apoptosis mechanisms
  • Drug resistance patterns

• Pharmaceutical Development

  • Novel delivery systems
  • Stability enhancement
  • Formulation optimization

• Clinical Research Support

  • Reference standards
  • Method development
  • Analytical testing

Safety & Handling Considerations

• Highly potent compound
• Requires controlled environment handling
• Proper PPE essential
• Cytotoxic material precautions
• Disposal protocols provided

Technical Support

• Method development assistance
• Analytical testing guidance
• Stability data available
• Handling protocols provided
• Documentation support

Regulatory Information

• Research use only
• DEA Schedule II controlled substance
• Restricted to authorized facilities
• Export control regulations apply
• Comprehensive safety documentation

Contact BIORLAB’s specialized technical team for detailed information, handling protocols, or custom requirements.

IMPORTANT: This compound is for research and development purposes only. Highly potent material requiring specialized handling. Not for human use without proper authorization.