Description

High-purity Vicine, an alkaloid glycoside primarily found in fava beans (Vicia faba), is known for its significant biological effects and toxicity in G6PD-deficient individuals.

Technical Specifications

• Molecular Formula: C₁₀H₁₆N₄O₇
• Molecular Weight: 304.26 g/mol
• Chemical Structure: 2,6-Diamino-5-(β-D-glucopyranosyloxy)pyrimidin-4(1H)-one
• Appearance: Crystalline powder
• Solubility: Water-soluble

IUPAC Name: 2,4-diamino-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrimidin-6-one

InChI: InChI=1S/C10H16N4O7/c11-7-6(8(19)14-10(12)13-7)21-9-5(18)4(17)3(16)2(1-15)20-9/h2-5,9,15-18H,1H2,(H5,11,12,13,14,19)/t2-,3-,4+,5-,9+/m1/s1

InChIKey: KGNGTSCIQCLKEH-SYCVNHKBSA-N

Canonical SMILES: C(C1C(C(C(C(O1)OC2=C(N=C(NC2=O)N)N)O)O)O)O

Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC2=C(N=C(NC2=O)N)N)O)O)O)O

Synonyms: Vicine; 152-93-2; Vicioside; 2,6-Diamino-5-(beta-D-glucopyranosyloxy)-(1H)-pyrimidin-4-one; NSC-95092; COL14PJW3X; C08437; CID 91446; …

Botanical Source:

Research Applications

1. Medical Research

   • G6PD deficiency studies
   • Hemolytic anemia research
   • Oxidative stress studies
   • ROS mechanism investigations

2. Animal Studies

   • Effects on laying hens
   • Impact on pig digestion
   • Rat toxicity studies
   • Feed intake research

Animal Study Results

1. Poultry Effects

   • Reduced feed intake
   • Decreased egg weight
   • Lower hemoglobin levels
   • Increased liver weights

2. Pig Studies

   • Minor effects on protein digestibility
   • Limited impact on energy digestibility
   • Minimal digestive system effects

Population Impact

• Global G6PD deficiency prevalence: 4.9%
• Affects over 400 million individuals worldwide
• Potentially life-threatening condition
• Requires prompt diagnosis and management

Storage & Handling

• Store protected from light
• Maintain controlled temperature
• Avoid moisture exposure
• Follow safety guidelines
• Use appropriate PPE

Quality Control

• Identity verification
• Purity assessment
• Stability monitoring
• Analytical documentation
• Batch traceability

Safety Information

Important Note: Toxic in individuals with G6PD deficiency

• Can cause severe hemolytic anemia
• Requires careful handling
• Medical supervision necessary
• Emergency protocols required

Research Support

• Technical consultation
• Analytical method support
• Safety data sheets
• Application Guidance
• Emergency protocols

Current Applications

1. Medical Research

   • G6PD deficiency studies
   • Favism research
   • Oxidative stress mechanisms
   • Treatment development

2. Agricultural Studies

   • Animal feed research
   • Toxicity evaluations
   • Digestibility studies
   • Safety assessments

For research and development purposes only. Not for human consumption. Handle with extreme caution due to potential toxicity in G6PD-deficient individuals.