Description

IUPAC Name: (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one

InChI: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChIKey: DFBIRQPKNDILPW-CIVMWXNOSA-N

Canonical SMILES: CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C

Isomeric SMILES: CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C

Synonyms: triptolide; 38748-32-2; Triptolid; PG490; NSC-163062; NSC 163062; 19ALD1S53J; CHEBI:9747; …

Botanical Source: Tripterygium wilfordii Hook.f.

⚠️ HIGHLY POTENT COMPOUND – EXTREME CAUTION REQUIRED

Product Overview

BIORLAB presents high-purity Triptolide, a potent diterpenoid with significant applications in cancer research and immunological studies. Requires stringent safety protocols.

Technical Specifications

• Chemical Formula: C₂₀H₂₄O₆
• Molecular Weight: 360.4 g/mol
• Source: Tripterygium wilfordii
• Purity: ≥98% (HPLC)
• Storage: -20°C, protected from light

⚠️ WARNING: Extremely potent. Specialized handling is required.

Key Research Applications

Primary Research Areas

1. Cancer Research

   • Apoptosis induction
   • Anti-proliferative studies
   • RNA polymerase II inhibition
   • Transcription regulation

2. Immunological Studies

   • Immunosuppression research
   • Inflammatory modulation
   • Autoimmune studies
   • T-cell response

Safety Protocols

Critical Precautions

• Dedicated safety equipment
• Double containment protocols
• Specialized PPE requirements
• Restricted access areas

Required PPE

• Chemical-resistant double gloves
• Protective lab coat
• Full face protection
• Respiratory protection

Research Significance

Biological Activities

1. Primary Effects

   • RNA Pol II inhibition
   • Transcription blocking
   • Cell death induction
   • Immune modulation

2. Molecular Targets

   • XPB protein
   • NF-κB pathway
   • HSP70 expression
   • p53 signaling

Storage Requirements

• Store at -20°C
• Triple containment
• Hazard labeling
• Access restrictions

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Safety documentation

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only. RESTRICTED USE.