Description
IUPAC Name: (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
InChI: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChIKey: UCFGDBYHRUNTLO-QHCPKHFHSA-N
Canonical SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
Isomeric SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
Synonyms: topotecan; 123948-87-8; Topotecan lactone; Hycamptamine; Hycamptin; (S)-Topotecan; Topotecane; Topotecanum; …
Botanical Source:
Product Overview
Topotecan, a semisynthetic derivative of camptothecin, is provided by BIORLAB at pharmaceutical-grade purity (≥98%). This compound demonstrates significant value in cancer research, particularly for ovarian, lung, and cervical cancer studies.
Technical Specifications
- Molecular Formula: C₂₃H₂₃N₃O₅
- Molecular Weight: 421.4 g/mol
- Appearance: Yellow crystalline powder
- Solubility: Soluble in water and methanol
- Purity: ≥98% (HPLC)
- Storage: -20°C
Key Research Applications
- Cancer Research
- Ovarian cancer studies
- Small cell lung cancer research
- Cervical cancer investigations
Mechanism of Action
- Topoisomerase I inhibition
- DNA strand breaks induction
- Cell cycle disruption
Storage & Handling
- Store at -20°C
- Protect from light
- Reconstituted solutions stable for 24 hours
- Special disposal procedures required
Quality Assurance
- Full spectroscopic data
- Certificate of Analysis
- Batch-specific testing
- Research-grade documentation
Research Focus Areas
- Clinical Studies
- Treatment resistance
- Combination therapy
- Dosage optimization
Technical Support Features
- Method development assistance
- Analytical testing guidance
- Stability data available
- Research protocol support
Safety & Regulatory Information
- Controlled substance regulations
- Complete safety documentation
- Special handling requirements
- Environmental protocols
For detailed technical information or custom requirements, contact BIORLAB’s scientific team.
WARNING: This compound is highly potent and for research use only. Requires specialized handling and safety protocols.