Topotecan

SKU 123948-87-8 Category

$30.00

CAS No.: 123948-87-8
Molecular Formula C₂₃H₂₃N₃O₅
Molecular Weight 421.4g/mol
Purity HPLC>98%
Chemical Family Alkaloids

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* Warning: BIORLAB’s Natural Compounds are for laboratory research purposes only.

Description


 

IUPAC Name: (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

InChI: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

InChIKey: UCFGDBYHRUNTLO-QHCPKHFHSA-N

Canonical SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O

Isomeric SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O

Synonyms: topotecan; 123948-87-8; Topotecan lactone; Hycamptamine; Hycamptin; (S)-Topotecan; Topotecane; Topotecanum; …

Botanical Source:


Product Overview

Topotecan, a semisynthetic derivative of camptothecin, is provided by BIORLAB at pharmaceutical-grade purity (≥98%). This compound demonstrates significant value in cancer research, particularly for ovarian, lung, and cervical cancer studies.

Technical Specifications

  • Molecular Formula: C₂₃H₂₃N₃O₅
  • Molecular Weight: 421.4 g/mol
  • Appearance: Yellow crystalline powder
  • Solubility: Soluble in water and methanol
  • Purity: ≥98% (HPLC)
  • Storage: -20°C

Key Research Applications

  • Cancer Research
    • Ovarian cancer studies
    • Small cell lung cancer research
    • Cervical cancer investigations

Mechanism of Action

  • Topoisomerase I inhibition
  • DNA strand breaks induction
  • Cell cycle disruption

Storage & Handling

  • Store at -20°C
  • Protect from light
  • Reconstituted solutions stable for 24 hours
  • Special disposal procedures required

Quality Assurance

  • Full spectroscopic data
  • Certificate of Analysis
  • Batch-specific testing
  • Research-grade documentation

Research Focus Areas

  • Clinical Studies
    • Treatment resistance
    • Combination therapy
    • Dosage optimization

Technical Support Features

  • Method development assistance
  • Analytical testing guidance
  • Stability data available
  • Research protocol support

Safety & Regulatory Information

  • Controlled substance regulations
  • Complete safety documentation
  • Special handling requirements
  • Environmental protocols

For detailed technical information or custom requirements, contact BIORLAB’s scientific team.


WARNING: This compound is highly potent and for research use only. Requires specialized handling and safety protocols.

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Most Common Questions

For you to better choose the right compounds,  and so the scientific research can be carried out smoothly, here are some FAQs.

Delivery times vary based on order size, We deliver small quantities of compounds within 2 working days, ranging from one week for up to 500 compounds to about 6 weeks for orders exceeding 5,000 compounds.

While our focus is on natural compounds, we can provide information on natural product-like synthetic compounds if requested.

  • Yes, we can assist in selecting compounds that may be relevant to specific biological targets based on their structural characteristics and known activities.

Yes, we provide comprehensive analytical data and certificates of analysis for all our compounds.

Yes, we can re-supply active compounds in larger quantities and offer analogs for further testing if hits are discovered.

We offer a wide range of natural compounds including alkaloids, terpenoids, flavonoids, coumarins, peptides, glycosides, and nucleosides isolated from plants.

Our compounds undergo rigorous purification processes and are tested using advanced analytical methods such as NMR, mass spectroscopy, and in some cases, X-ray analysis to ensure >98% purity.

Yes, we offer custom isolation services for specific natural compounds based on client requirements.

We typically offer quantities ranging from 2 mg to 100 mg for screening purposes, with larger amounts available upon request.

We use various physicochemical analytical methods, including NMR (300-500 MHz) and mass spectroscopy, to confirm structures and stereochemistry.

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