Description

IUPAC Name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone

InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

InChIKey: QJJXYPPXXYFBGM-LFZNUXCKSA-N

Canonical SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC

Isomeric SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC

Synonyms: tacrolimus; Fujimycin; 104987-11-3; Prograf; Tsukubaenolide; Tacrolimus anhydrous; Protopic; Anhydrous Tacrolimus; …

Botanical Source:

BIORLAB offers pharmaceutical-grade tacrolimus (FK506), a potent macrolide immunosuppressant originally isolated from Streptomyces tsukubaensis. Our high-purity tacrolimus supports advanced research in transplant medicine, immunology, and pharmaceutical development, meeting stringent quality requirements for research applications.

Technical Specifications

• Molecular Formula: C₄₄H₆₉NO₁₂
• CAS Number: 104987-11-3
• Purity: ≥98%
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO, ethanol, and methanol

Key Features and Benefits

• Superior Quality: Advanced purification technology ensures the highest purity
• Full Characterization: Comprehensive analytical documentation including HPLC, NMR, and MS
• Research Grade: Suitable for pharmaceutical development and preclinical studies
• Batch Consistency: Rigorous quality control between productions
• Stability-Optimized: Enhanced storage conditions for maximum shelf life

Research Applications

• Transplant Research: Immunosuppression studies
• Immunology Studies: T-cell response investigations
• Pharmaceutical Development: Novel formulation research
• Cell Signaling Studies: Calcineurin Inhibition Research
• Drug Delivery: Bioavailability enhancement studies

Industry Applications

• Pharmaceutical R&D
• Immunology Research
• Transplant Medicine
• Clinical Studies
• Drug Development Programs

Quality Assurance

Each batch undergoes comprehensive testing:

• Identity confirmation through multiple analytical methods
• Purity verification using validated HPLC protocols
• Structure elucidation via spectroscopic analysis
• Stability assessment under controlled conditions
• Impurity profiling and characterization
• Sterility testing

Storage and Handling

• Store at -20°C under an inert atmosphere
• Protect from light and moisture
• Shelf life: 24 months when properly stored
• Available in research quantities
• Special handling precautions required

Innovation Potential

Our tacrolimus supports research in:

• Novel drug delivery systems
• Targeted immunosuppression
• Formulation optimization
• Bioavailability enhancement
• Combination therapy development

Regulatory Compliance

• Manufactured in ISO-certified facilities
• Follows cGMP guidelines
• Complete documentation available
• Meets international pharmacopeia standards
• Suitable for research purposes only

Scientific Evidence

• Well-characterized mechanism of action
• Established immunological effects
• Documented stability profile
• Verified potency
• Comprehensive safety data

Contact BIORLAB’s technical support team for detailed specifications, custom requirements, or bulk ordering information.