Description

IUPAC Name: (1S,2S,4S,5’R,6R,7S,8R,9S,12S,13R,16S)-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2′-piperidine]-16-ol

InChI: InChI=1S/C27H43NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28-29H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1

InChIKey: KWVISVAMQJWJSZ-VKROHFNGSA-N

Canonical SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)NC1

Isomeric SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O)C)C)C)NC1

Synonyms: solasodine; 126-17-0; Purapuridine; Solasodin; Solancarpidine; Solanidine-S; Solasod-5-en-3beta-ol; CHEBI:9190; …

Botanical Source: Solanum nigrum L.

Technical Specifications

• Molecular Formula: C₂₇H₄₃NO₂
• Source: Solanum species
• Class: Steroidal alkaloid
• Purity: ≥98% (HPLC)
• Storage: -20°C, protected from light

Research Applications

Primary Research Areas

1. Cancer Research

   • Pancreatic cancer studies
   • Anti-tumor activity
   • Cell proliferation inhibition
   • Apoptosis induction

2. Molecular Pathways

   • Cox-2/Akt/GSK3β pathway
   • Cytochrome c release
   • Caspases cascade
   • Cell signaling studies

Key Research Properties

1. Anti-tumor Effects

   • Inhibits cancer cell proliferation
   • Promotes apoptosis
   • Stimulates immunity
   • Regulates signaling pathways

2. Cell Line Studies

   • SW1990 cells
   • PANC1 cells
   • Migration inhibition
   • Invasion reduction

Research Significance

1. Cancer Treatment

   • Potent anti-tumor activities
   • Low cytotoxicity
   • Enhanced immune response
   • Multiple mechanisms

2. Immune Modulation

   • Increased TNF-α levels
   • Enhanced IL-2 production
   • Elevated IFN-γ levels
   • Immune system stimulation

Molecular Mechanisms

• Inhibits Cox-2/Akt/GSK3β pathway
• Enhances cytochrome c release
• Activates caspase-3 and caspase-9
• Regulates Bcl-2/Bax ratio

Storage & Handling

• Store at -20°C
• Protect from light
• Available in research quantities
• Stability data provided

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Research-grade documentation

Target Applications

• Cancer research centers
• Pharmaceutical R&D
• Academic institutions
• Drug development

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only.