Description
IUPAC Name: (1S,2S,4S,5’R,6R,7S,8R,9S,12S,13R,14R,16R)-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2′-oxane]-14,16-diol
InChI: InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey: QMQIQBOGXYYATH-IDABPMKMSA-N
Canonical SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)O)O)C)C)C)OC1
Isomeric SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5([C@@H](C[C@@H](C6)O)O)C)C)C)OC1
Synonyms: Ruscogenin; 472-11-7; C27H42O4; BXI92R2VUJ; CHEBI:8913; (1beta,3beta,25R)-Spirost-5-ene-1,3-diol; (25R)-spirost-5-en-1beta,3beta-diol; UNII-BXI92R2VUJ; …
Botanical Source: Ophiopogonis Radix
Product Overview
High-purity Ruscogenin, a natural steroidal sapogenin isolated from Ruscus aculeatus and Radix Ophiopogon japonicus, manufactured to exceptional standards for pharmaceutical research.
Technical Specifications
- Molecular Formula: C₂₇H₄₂O₄
- Molecular Weight: 430.6 g/mol
- Purity: ≥98% (HPLC)
- Appearance: White crystalline powder
- Solubility: Soluble in DMSO, ethanol; poorly soluble in water
Key Features & Benefits
- Natural steroidal sapogenin
- Potent anti-inflammatory properties
- Demonstrated antioxidant effects
- Validated vascular protection
Research Applications
-
Anti-inflammatory Research
- NF-κB pathway studies
- ICAM-1 expression modulation
- Leukocyte migration inhibition
- TNF-α induced responses
-
Gastric Research
- Ulcer treatment studies
- MPO level reduction
- GSH and GSH-Px modulation
- Oxidative stress research
-
Vascular Studies
- Endothelial cell research
- Adhesion molecule studies
- Inflammatory mediators
- Cytokine modulation
Mechanism of Action
- Inhibits leukocyte adhesion
- Suppresses TNF-α-induced ICAM-1 expression
- Reduces NF-κB activation and DNA binding
- Enhances antioxidant metabolism
Storage & Handling
- Store at -20°C
- Protect from light and moisture
- Avoid repeated freeze-thaw cycles
- Stock solution guidelines provided
- 24-month stability under recommended conditions
Quality Assurance
- GMP-compliant manufacturing
- Rigorous quality control
- Complete analytical documentation
- Traceable lot numbers
- Stability monitoring program
Research Support
BIORLAB provides:
- Technical consultation
- Analytical method support
- Stability data
- Custom synthesis options
- Application Guidance
Key Research Areas
-
Inflammatory Disorders
- Vascular inflammation
- Gastric ulcers
- Cellular adhesion
- Inflammatory signaling
-
Oxidative Stress
- Antioxidant mechanisms
- Free radical scavenging
- GSH metabolism
- MPO modulation
-
Vascular Protection
- Endothelial function
- Leukocyte adhesion
- Inflammatory response
- Cell signaling pathways
This premium-grade Ruscogenin is specifically designed for research institutions and pharmaceutical companies advancing therapeutic development and scientific research.
For research and development purposes only. Not for human consumption or clinical use.
[Contact BIORLAB’s technical support team for detailed specifications and custom requirements]