Description

IUPAC Name: methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

InChI: InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

InChIKey: QEVHRUUCFGRFIF-MDEJGZGSSA-N

Canonical SMILES: COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

Isomeric SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

Synonyms: reserpine; 50-55-5; Serpalan; Apoplon; Serpasil; Alserin; Hypersil; Sandril; …

Botanical Source: Rauvolfia verticillata

Product Overview

BIORLAB provides Reserpine, an alkaloid from Rauwolfia serpentina, at pharmaceutical-grade purity (≥98%). This compound has significant research applications in antihypertensive and neuroscience studies.

Technical Specifications

• Molecular Formula: C₃₃H₄₀N₂O₉
• Molecular Weight: 608.68 g/mol
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in acetone, and ethyl acetate; slightly soluble in ethanol
• Purity: ≥98% (HPLC)
• Melting Point: 152-157°C

Key Research Applications

• Cardiovascular Research
  • Hypertension studies
  • Sympathetic nerve function
  • Blood pressure regulation
• Neuroscience Research
  • Neurotransmitter storage
  • Vesicular transport studies
  • Psychiatric disorder research

Mechanism of Action

• Blocks VMAT-2 (vesicular monoamine transporter-2)
• Depletes catecholamines
• Inhibits neurotransmitter storage
• Modulates sympathetic activity

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Available in research quantities
• Stability data provided

Quality Assurance

• Full analytical documentation
• Comprehensive Certificate of Analysis
• Batch-specific purity data
• Research-grade validation

Research Significance

1. Pharmacological Properties

   • Onset: 3-6 days
   • Duration: 2-6 weeks
   • Bioavailability: 50%

2. Clinical Research Applications

   • Hypertension studies
   • Psychiatric disorder investigations
   • Drug mechanism research

Safety Considerations

• Controlled storage required
• May cause CNS effects
• Monitor for depression
• Proper PPE essential

Contraindications for Research

• Active peptic ulcer studies
• Depression research
• Electroconvulsive therapy
• Pregnancy studies

Technical Support Features

• Method development assistance
• Analytical testing guidance
• Stability data available
• Research protocol support

Application Areas

1. Pharmaceutical Research

   • Drug development
   • Mechanism studies
   • Formulation research

2. Clinical Studies

   • Reference standards
   • Method validation
   • Quality control

For detailed technical information or custom requirements, contact BIORLAB’s scientific team.

IMPORTANT: This compound is for research and development purposes only. Not for human use without proper authorization.