Description

IUPAC Name: [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate

InChI: InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1

InChIKey: PHEDXBVPIONUQT-RGYGYFBISA-N

Canonical SMILES: CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

Isomeric SMILES: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C

Synonyms: Phorbol 12-myristate 13-acetate; 16561-29-8; 12-O-Tetradecanoylphorbol-13-acetate; phorbol-12-myristate-13-acetate; 12-O-Tetradecanoylphorbol 13-acetate; Tetradecanoylphorbol acetate; Phorbol ester; Factor A1; …

Botanical Source: Croton tiglium L.

Product Overview

BIORLAB presents high-purity Phorbol 12-myristate 13-acetate (PMA/TPA), a potent protein kinase C activator widely used in cell signaling and cancer research.

Technical Specifications

• Chemical Formula: C₃₆H₅₆O₈
• Molecular Weight: 616.8 g/mol
• CAS: 16561-29-8
• Purity: ≥98% (HPLC)
• Storage: -20°C, protected from light

Key Research Applications

Primary Research Areas

1. Cell Signaling

   • PKC activation studies
   • Signal transduction
   • Cell differentiation
   • Tumor promotion

2. Cancer Research

   • Cell proliferation
   • Apoptosis studies
   • Inflammation research
   • Tumor biology

⚠️ CAUTION: Potent tumor promoter. Handle with extreme care.

Research Significance

Biological Activities

1. Primary Effects

   • PKC activation
   • Cell differentiation
   • inflammatory response
   • Gene expression

2. Cellular Responses

   • MAPK activation
   • Transcription regulation
   • Cell cycle control
   • Oxidative burst

Safety & Handling

Critical Precautions

• Use dedicated safety equipment
• Double glove procedure
• Contained workspace
• Proper disposal protocols

Required PPE

• Chemical-resistant gloves
• Lab coat
• Eye protection
• Face shield when weighing

Storage Requirements

• Store at -20°C
• Double containment
• Hazard labeling
• Access Restrictions

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Safety documentation

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only. RESTRICTED USE.