Description

IUPAC Name: (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-5-one

InChI: InChI=1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18-,19-,20-/m1/s1

InChIKey: QGVLYPPODPLXMB-UBTYZVCOSA-N

Canonical SMILES: CC1C(C2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)O)O

Isomeric SMILES: C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)O)O

Synonyms: PHORBOL; 17673-25-5; CHEBI:8116; 4alpha-Phorbol; XUZ76S9127; 4,9,12beta,13,20-pentahydroxy-1,6-tigliadien-3-on; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one; 4,9,12-beta,13,20-Pentahydroxy-1,6-tigliadien-3-on; …

Botanical Source: Croton tiglium L.

Product Overview

Phorbol is a tetracyclic diterpenoid with significant biological activity and pharmaceutical research applications. BIORLAB provides high-purity phorbol isolated through advanced chromatographic techniques for cutting-edge research applications.

Technical Specifications

• Molecular Formula: C₂₀H₂₈O₆
• Molecular Weight: 364.4 g/mol
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO, methanol, ethanol
• Melting Point: 204-208°C

Storage and Handling

• Store at -20°C in sealed containers
• Protect from light and moisture
• Stability: 18 months when properly stored
• Stock solution: Prepare in DMSO
• Use within 24 hours once in solution

Key Research Applications

Signal Transduction Research

• Protein Kinase C activation studies
• Cell signaling pathways
• Second messenger systems
• Cellular response mechanisms

Cancer Research

• Anti-tumor mechanisms
• Cell differentiation studies
• Apoptosis pathways
• Drug development

Molecular Biology

• Gene expression studies
• Cell proliferation research
• Signal cascade investigation
• Membrane trafficking

Quality Assurance

• HPLC purity analysis
• Structure verified by NMR
• Complete Certificate of Analysis
• Batch-specific documentation
• Stringent quality control

Research Benefits

• High biological activity
• Excellent batch consistency
• Comprehensive documentation
• Enhanced stability
• Superior purity

Research Applications Highlights

1. Signal Transduction

   • PKC activation
   • Cellular signaling
   • Membrane dynamics
   • Second messenger pathways

2. Cancer Studies

   • Cell proliferation control
   • Differentiation mechanisms
   • Apoptotic pathways
   • Drug resistance research

3. Cellular Mechanisms

   • Signal transduction
   • Gene regulation
   • Protein interactions
   • Membrane biology

Why Choose BIORLAB’s Phorbol?

• Industry-leading purity
• Expert technical support
• Full analytical documentation
• Competitive Pricing
• Global shipping capability
• Custom synthesis options

Technical Support

• Method development assistance
• Analytical protocols
• Stability data
• Storage recommendations
• Safety guidelines

For research use only. Not for human consumption or therapeutic use.