Description

IUPAC Name: (1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one

InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

InChIKey: KTEXNACQROZXEV-PVLRGYAZSA-N

Canonical SMILES: CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

Isomeric SMILES: C/C/1=CCC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C

Synonyms: parthenolide; 20554-84-1; (-)-Parthenolide; MFCD00134592; CHEBI:7939; CHEMBL465158; NSC-157035; (1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one; …

Botanical Source: Magnolia liliflora Desr

Product Overview

BIORLAB presents high-purity Parthenolide, a sesquiterpene lactone with significant applications in cancer research, particularly targeting leukemia stem cells and demonstrating anti-inflammatory properties.

Technical Specifications

• Chemical Formula: C₁₅H₂₀O₃
• Source: Tanacetum parthenium (Feverfew)
• Molecular Weight: 248.32 g/mol
• Purity: ≥98% (HPLC)
• Storage: -20°C, protected from light

Key Research Applications

Cancer Research

1. Cancer Stem Cell Studies

   • Leukemia stem cell targeting
   • NF-κB pathway inhibition
   • p53 pathway activation
   • HDAC1 inhibition

2. Molecular Mechanisms

   • Oxidative stress induction
   • DNA methyltransferase inhibition
   • Epigenetic modification
   • Apoptosis induction

Research Significance

Biological Activities

1. Anti-cancer Effects

   • Selective cancer stem cell targeting
   • Multiple pathway modulation
   • Epigenetic regulation
   • Redox status alteration

2. Anti-inflammatory Properties

   • NF-κB pathway inhibition
   • Cytokine modulation
   • Inflammatory mediator reduction
   • Oxidative stress control

Storage & Handling

• Store at -20°C
• Protect from light
• Available in research quantities
• Stability data provided
• Handle with appropriate PPE

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Research-grade documentation

BIORLAB Advantage

• Industry-leading purity
• Consistent quality
• Technical support
• Custom packaging options
• Comprehensive documentation

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only.