Description

Pangelin (4-[(2R)-2-hydroxy-3-methylbut-3-enoxy]furo[3,2-g]chromen-7-one) is a natural prenylated furanocoumarin isolated from the roots of Angelica dahurica and aerial parts of Ducrosia anethifolia. BIORLAB offers high-purity pangelin for advanced pharmaceutical research applications, extracted using proprietary techniques that maintain the compound’s natural bioactivity and structural integrity.

Technical Specifications

• Appearance: White to off-white crystalline powder
• Molecular Weight: 286.28 g/mol
• Purity: ≥98% (HPLC validated)
• Optical Rotation: [α]D20 corresponds to (2R) configuration
• Solubility: Soluble in chloroform, dichloromethane, ethyl acetate, DMSO, acetone

IUPAC Name: 4-[(2R)-2-hydroxy-3-methylbut-3-enoxy]furo[3,2-g]chromen-7-one

InChI: InChI=1S/C16H14O5/c1-9(2)12(17)8-20-16-10-3-4-15(18)21-14(10)7-13-11(16)5-6-19-13/h3-7,12,17H,1,8H2,2H3/t12-/m0/s1

InChIKey: BVMOMQJYQYBMKL-LBPRGKRZSA-N

Canonical SMILES: CC(=C)C(COC1=C2C=CC(=O)OC2=CC3=C1C=CO3)O

Isomeric SMILES: CC(=C)[C@H](COC1=C2C=CC(=O)OC2=CC3=C1C=CO3)O

Synonyms: Pangelin; 33783-80-1; 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((2-hydroxy-3-methyl-3-butenyl)oxy)-, (R)-; R-(+)-Pangelin; 4-[(2R)-2-hydroxy-3-methylbut-3-enoxy]furo[3,2-g]chromen-7-one; (R)-4-((2-Hydroxy-3-methylbut-3-en-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one; MLS002472950; CHEMBL1870203; …

Botanical Source:

Storage and Handling

• Store desiccated at -20°C
• Protect from light and moisture
• For higher solubility, warm to 37°C and use ultrasonic bath
• Stock solutions can be stored below -20°C for several months
• Recommended to prepare fresh solutions on the day of use
• Allow vial to reach room temperature for at least an hour before opening

Biological Activities and Research Applications

Antimicrobial Research

• Anti-mycobacterial Activity: Demonstrates activity against fast-growing mycobacteria including M. fortuitum, M. aurum, M. phlei, and M. smegmatis with MIC values ranging from 64-128 μg/mL
• Natural Antibiotic Research: Valuable for studies on novel antimicrobial compounds from natural sources

Cancer Research

• Cytotoxic Properties: Exhibits potent cytotoxic activity against multiple tumor cell lines including L1210, HL-60, K562, and B16F10 with IC50 values of 8.6-14.6 μg/mL
• Anticancer Drug Development: Important scaffold for developing novel anticancer agents
• Cell Signaling Research: Useful for investigation of cellular pathways affected by coumarin derivatives

Pharmaceutical Development

• Lead Compound: Serves as a template for structure-activity relationship studies
• Natural Product Chemistry: Important for understanding bioactive components in traditional medicinal plants
• Medicinal Chemistry: Valuable scaffold for synthetic modifications and drug design

Source and Extraction

• Naturally occurring in the roots of Angelica dahurica
• Also found in aerial parts of Ducrosia anethifolia
• Extracted using advanced chromatographic techniques
• Structurally characterized using comprehensive 1D and 2D NMR studies

Quality Assurance

Each batch of BIORLAB’s pangelin undergoes:

• High-performance liquid chromatography (HPLC) analysis
• Mass spectrometry confirmation
• Nuclear magnetic resonance (NMR) verification
• Complete certificate of analysis documentation
• Stringent purity assessment (>98%)

Research Value

• Pure, well-characterized natural compound
• Important for pharmacological screening
• Valuable for drug discovery programs
• Essential for understanding coumarin bioactivity
• Critical for structure-activity relationship studies

For research use only. Not for human consumption or clinical use. All BIORLAB products are intended solely for laboratory research applications.

For detailed specifications, bulk quantities, or technical support, please contact BIORLAB’s scientific team.