Description

IUPAC Name: [(3S,5R,8R,9S,10S,13R,14S,16S,17R)-14-hydroxy-3-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate

InChI: InChI=1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17-,20+,21-,22-,23+,24-,25-,27-,28-,29-,30-,31+,32-/m0/s1

InChIKey: JLPDBLFIVFSOCC-XYXFTTADSA-N

Canonical SMILES: CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CC(C5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O

Isomeric SMILES: C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3CC[C@]5([C@@]4(C[C@@H]([C@@H]5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O

Synonyms: OLEANDRIN; 465-16-7; Foliandrin; Neriolin; Folinerin; Neriostene; Oleandrina; Anvirzel; …

Botanical Source: Nerium indicum Mill.

Product Overview

BIORLAB presents high-purity Oleandrin (CAS: 465-16-7), a potent cardiac glycoside crucial for specialized research applications in cancer and cardiovascular studies. Our pharmaceutical-grade compound supports advanced research in targeted therapeutic development.

Important Safety Notice

⚠️ HIGH TOXICITY ALERT: Oleandrin is a highly toxic compound requiring strict handling protocols and appropriate containment facilities. For authorized research use only.

Technical Specifications

• Molecular Formula: C₃₂H₄₈O₉
• Molecular Weight: 576.7 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White crystalline powder
• Storage: -20°C, sealed, protected from light

Key Research Applications

Cancer Research

1. Anti-tumor Studies

   • Cancer cell proliferation inhibition
   • Apoptosis induction
   • Cell signaling pathway modulation
   • GRP78 stress induction inhibition

2. Therapeutic Research

   • MAPK pathway studies
   • NF-κB signaling investigation
   • Osteoclast differentiation research
   • LRP4 targeting studies

Research Significance

Molecular Mechanisms

1. Signaling Pathways

   • MAPK pathway modulation
   • NF-κB pathway regulation
   • LRP4 targeting
   • Multiple cellular responses

2. Cellular Effects

   • Osteoclast differentiation inhibition
   • Anti-inflammatory action
   • Cell cycle regulation
   • Stress response modulation

Storage & Handling

• Store at -20°C
• Double containment required
• Certified facilities only
• Strict safety protocols
• Hazardous waste disposal

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Research-grade documentation
• Safety data sheets

BIORLAB Advantage

• Industry-leading purity
• Stringent safety protocols
• Expert technical support
• Controlled distribution
• Comprehensive documentation

For detailed technical information and requirements, contact BIORLAB’s scientific team.

Note: This product is RESTRICTED for authorized laboratory research use only. NOT for human use.