Description

High-purity Neohesperidin Dihydrochalcone (NHDC), synthesized from citrus-derived neohesperidin, offers up to 1,500-2,000 times the sweetness of sucrose. This compound demonstrates significant antioxidant and anti-inflammatory properties.

Technical Specifications

• Molecular Formula: C₂₈H₃₆O₁₅
• Molecular Weight: 612.6 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to yellow odorless powder
• Solubility: Limited water solubility, stable to heat

Key Features & Benefits

• Natural sweetener alternative
• Anti-oxidative properties
• Anti-inflammatory activity
• Anti-apoptotic effects
• Zero caloric value

IUPAC Name: 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one

InChI: InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

InChIKey: ITVGXXMINPYUHD-CUVHLRMHSA-N

Canonical SMILES: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O

Isomeric SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O

Synonyms: neohesperidin dihydrochalcone; 20702-77-6; Nhdc; Neohesperidin dc; Neosperidin dihydrochalcone; Neohesperidin dhc; Neohesperidine dihydrochalcone; Neohesperidin-dihydrochalcone; …

Botanical Source: Aurantii fructus immaturus

Research Applications

1. Pharmaceutical Research

   • Liver injury protection studies
   • Blood sugar regulation
   • Cholesterol reduction research
   • Drug bitterness masking

2. Food Science Applications

   • Sweetener development
   • Flavor enhancement
   • Taste modification studies
   • Combined sweetener research

3. Health Studies

   • Diabetes research
   • Cardiovascular health
   • Liver protection
   • Anti-inflammatory mechanisms

Regulatory Status

• Approved by European Union (E959)
• FDA-approved as a flavor enhancer
• Used in pharmaceuticals and livestock feed
• Approved for various food applications

Storage & Handling

• Store in cool, dry conditions
• Protect from light and moisture
• Stock solution guidelines provided
• Stable under normal conditions

Key Research Areas

1. Therapeutic Applications

   • Anti-oxidative effects
   • Anti-inflammatory properties
   • Liver protection
   • Metabolic regulation

2. Commercial Development

   • Pharmaceutical tablets
   • Soft drinks
   • Dairy products
   • Confectionery

Quality Assurance

• GMP-compliant manufacturing
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Usage Considerations

• Must be combined with other sweeteners
• It has an intense cooling effect on the tongue
• Exhibits licorice-like taste
• Slow onset and distinctive aftertaste

This premium-grade NHDC is designed for research institutions and companies advancing therapeutic development and food science applications.

For research and development purposes only. Not for direct consumption without appropriate approval.

[Contact BIORLAB’s technical support team for detailed specifications and custom requirements]