Description

High-purity Loganin, a bioactive iridoid glycoside naturally occurring in Cornus officinalis (Cornaceae) and other medicinal plants, demonstrating significant neuroprotective, anti-inflammatory, and hepatoprotective properties.

Technical Specifications

• Molecular Formula: C₁₇H₂₆O₁₀
• Molecular Weight: 390.4 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White crystalline powder
• Solubility: Soluble in methanol, DMSO; moderately soluble in water

IUPAC Name: methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate

InChI: InChI=1S/C17H26O10/c1-6-9(19)3-7-8(15(23)24-2)5-25-16(11(6)7)27-17-14(22)13(21)12(20)10(4-18)26-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9-,10+,11+,12+,13-,14+,16-,17-/m0/s1

InChIKey: AMBQHHVBBHTQBF-UOUCRYGSSA-N

Canonical SMILES: CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O

Isomeric SMILES: C[C@H]1[C@H](C[C@H]2[C@@H]1[C@@H](OC=C2C(=O)OC)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O

Synonyms: Loganin; 18524-94-2; Loganoside; 7-Hydroxy-6-desoxyverbenalin; CHEBI:15771; UNII-H7WJ16Q93C; H7WJ16Q93C; EINECS 242-398-0; …

Botanical Source: Cornus officinalis Sieb.et Zucc.

Key Research Applications

1. Neuroscience Research

   • Neuroprotective studies
   • Cognitive function improvement
   • Neurodegenerative disease research
   • Memory enhancement investigations

2. Inflammatory Studies

   • Anti-inflammatory mechanisms
   • Cytokine modulation
   • NF-κB pathway research
   • Oxidative stress reduction

3. Hepatic Research

   • Liver protection studies
   • Hepatic enzyme regulation
   • Metabolic pathway analysis
   • Antioxidant mechanisms

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Package Sizes

• 5mg
• 10mg
• 25mg
• 100mg
• Bulk quantities available

Biological Activities

1. Neuroprotective Effects

   • BBB penetration
   • Neuronal cell protection
   • Cognitive enhancement
   • Anti-neuroinflammatory properties

2. Anti-inflammatory Properties

   • Pro-inflammatory cytokine reduction
   • NF-κB pathway modulation
   • COX-2 inhibition
   • Inflammatory mediator regulation

3. Hepatoprotective Actions

   • Liver enzyme normalization
   • Oxidative stress reduction
   • Metabolic regulation
   • Cellular protection

Research Support Features

• Method validation protocols
• Analytical standards
• Technical consultation
• Custom synthesis options
• Application Guidance

Current Research Areas

1. Neurodegenerative Diseases

   • Alzheimer’s research
   • Parkinson’s studies
   • Cognitive decline
   • Neuroprotection mechanisms

2. Inflammatory Conditions

   • Chronic inflammation
   • Autoimmune disorders
   • Inflammatory mediators
   • Signal transduction

This premium-grade Loganin is specifically designed for research institutions and pharmaceutical companies advancing therapeutic development and scientific research.

For research and development purposes only. Not for human consumption or clinical use.