Description

IUPAC Name: (1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6,10-trien-17-ol

InChI: InChI=1S/C20H26O3/c1-18-7-5-16-14(6-9-23-16)15(18)4-8-19-10-13(2-3-17(18)19)20(22,11-19)12-21/h5-7,9,13,15,17,21-22H,2-4,8,10-12H2,1H3/t13-,15-,17+,18-,19+,20+/m1/s1

InChIKey: JEKMKNDURXDJAD-HWUKTEKMSA-N

Canonical SMILES: CC12C=CC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3

Isomeric SMILES: C[C@@]12C=CC3=C([C@H]1CC[C@]45[C@H]2CC[C@H](C4)[C@](C5)(CO)O)C=CO3

Synonyms: Kahweol; 6894-43-5; CCRIS 1521; KX95B6688Y; (3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b-decahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol; 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-; 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-, (3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-; 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-; …

Botanical Source: Coffee Cherry

Product Overview

High-purity Kahweol, a natural diterpene isolated from Coffea arabica, is manufactured to exceptional standards for pharmaceutical and cancer research.

Technical Specifications

• Molecular Formula: C₂₀H₂₆O₃
• Molecular Weight: 314.4 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO, ethanol; poorly soluble in water

Key Features & Benefits

• Natural coffee diterpene
• Anti-carcinogenic properties
• Validated structure and activity
• Comprehensive Certificate of Analysis
• Full spectroscopic characterization

Research Applications

1. Cancer Research

   • Anti-proliferative studies
   • Apoptosis mechanisms
   • Cell cycle regulation
   • Anti-angiogenic research

2. Pharmaceutical Development

   • Anti-inflammatory studies
   • Antioxidant research
   • Drug discovery screening
   • Toxicology investigations

3. Mechanism Studies

   • Cell signaling pathways
   • NF-κB modulation
   • Oxidative stress research
   • Molecular target identification

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Research Support

BIORLAB provides:

• Technical consultation
• Analytical method support
• Stability data
• Custom synthesis options
• Application Guidance

Key Research Areas

1. Cancer Biology

   • Tumor suppression
   • Metastasis inhibition
   • Cancer cell apoptosis
   • Anti-angiogenic mechanisms

2. Inflammation Research

   • Cytokine modulation
   • NF-κB pathway
   • COX-2 inhibition
   • Inflammatory mediators

3. Antioxidant Studies

   • Free radical scavenging
   • Oxidative stress
   • Cellular protection
   • ROS modulation

This premium-grade Kahweol is specifically designed for research institutions and pharmaceutical companies advancing therapeutic development and scientific research.

For research and development purposes only. Not for human consumption or clinical use.

[Contact BIORLAB’s technical support team for detailed specifications and custom requirements]