Description
High-purity Ingenol, a naturally occurring diterpenoid isolated from Euphorbia species, particularly E. peplus. This compound demonstrates significant biological activities including protein kinase C (PKC) modulation and anti-cancer properties.
Technical Specifications
- Molecular Formula: C₂₀H₂₈O₅
- Molecular Weight: 348.4 g/mol
- Purity: ≥98% (HPLC)
- Appearance: White crystalline powder
- Solubility: Soluble in DMSO, and methanol; limited water solubility
IUPAC Name: (1S,4S,5R,6R,9S,10R,12R,14R)-4,5,6-trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyltetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one
InChI: InChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13,3)4)12(17(19)24)6-11(8-21)16(23)20(19,25)15(9)22/h6-7,10,12-16,21-23,25H,5,8H2,1-4H3/t10-,12+,13-,14+,15+,16-,19+,20-/m1/s1
InChIKey: VEBVPUXQAPLADL-POYOOMFHSA-N
Canonical SMILES: CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO
Isomeric SMILES: C[C@@H]1C[C@@H]2[C@@H](C2(C)C)[C@@H]3C=C([C@H]([C@]4([C@@]1(C3=O)C=C([C@@H]4O)C)O)O)CO
Synonyms: ingenol; 30220-46-3; (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one; (+)-Ingenol; IC77UZI9G8; CHEBI:5922; (1S,4S,5R,6R,9S,10R,12R,14R)-4,5,6-trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyltetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one; UNII-IC77UZI9G8; …
Botanical Source: Euphorbia lathyris L
Key Features & Benefits
- Natural diterpenoid compound
- Validated structure and purity
- PKC modulation activity
- Comprehensive Certificate of Analysis
- Full analytical documentation
- Complete traceability
Research Applications
-
Cancer Research
- PKC activation studies
- Anti-tumor mechanisms
- Cell signaling pathways
- Apoptosis induction
-
Dermatological Research
- Skin cancer studies
- Actinic keratosis research
- Topical treatment development
- Drug delivery systems
-
Mechanism Studies
- Signal transduction
- Protein kinase modulation
- Cell death pathways
- Inflammatory responses
Storage & Handling
- Store at -20°C
- Protect from light and moisture
- Avoid repeated freeze-thaw cycles
- Stock solution guidelines provided
- 12-month stability under recommended conditions
Quality Assurance
- GMP-compliant manufacturing
- Rigorous quality control
- Full analytical documentation
- Traceable lot numbers
- Stability monitoring program
Package Sizes
- 1mg
- 5mg
- 10mg
- 25mg
- Custom quantities available
Biological Activities
-
PKC Modulation
- Specific PKC isoform activation
- Signal cascade initiation
- Cellular response regulation
- Therapeutic targeting
-
Anti-cancer Effects
- Cell growth inhibition
- Apoptosis induction
- Anti-tumor activity
- Cancer cell specificity
Research Support
BIORLAB provides:
- Technical consultation
- Analytical method support
- Stability data
- Custom synthesis options
- Application Guidance
Key Research Areas
-
Oncology Studies
- Mechanism of action
- Drug development
- Combination therapy
- Resistance studies
-
Dermatological Applications
- Topical formulations
- Drug delivery
- Efficacy studies
- Safety assessment
This premium-grade Ingenol is designed for research institutions and pharmaceutical companies advancing therapeutic development and scientific research.
For research and development purposes only. Not for human consumption or clinical use.