Description

IUPAC Name: (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione

InChI: InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1

InChIKey: WDXRGPWQVHZTQJ-OSJVMJFVSA-N

Canonical SMILES: CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Isomeric SMILES: C/C=C/1C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

Synonyms: (Z)-Guggulsterone; Z-Guggulsterone; Guggulsterone; 39025-23-5; 95975-55-6; Guggulsterones Z; Cis-Guggulsterone; Guggulsterone E&Z; …

Botanical Source:

Product Overview

BIORLAB presents high-purity Guggulsterone (CAS: 39025-23-5), a bioactive steroid ketone derived from Commiphora mukul, essential for metabolic and anti-inflammatory research. Our pharmaceutical-grade compound is available in both E and Z isomers, supporting advanced studies in cholesterol regulation and inflammatory responses.

Technical Specifications

• Molecular Formula: C₂₁H₂₈O₂
• Molecular Weight: 312.4 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Isomers: E and Z configurations available
• Storage: -20°C, protected from light

Key Research Applications

Metabolic Research

1. Lipid Metabolism

   • Cholesterol regulation
   • FXR antagonist studies
   • Bile acid signaling
   • Nuclear receptor research

2. Anti-inflammatory Studies

   • NF-κB pathway modulation
   • Inflammatory mediator regulation
   • Cytokine expression
   • COX-2 inhibition

Research Significance

Biological Activities

1. Molecular Targets

   • FXR antagonism
   • Nuclear receptor modulation
   • Transcription factor regulation
   • Signal transduction

2. Therapeutic Potential

   • Lipid metabolism
   • Anti-inflammatory effects
   • Thyroid function
   • Metabolic disorders

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Available in research quantities
• Stability data provided
• Handle with appropriate PPE

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Research-grade documentation
• Stability testing data

BIORLAB Advantage

• Industry-leading purity
• Both isomers available
• Technical support
• Custom packaging options
• Comprehensive documentation

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only.