Description

IUPAC Name: (5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

InChI: InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChIKey: VJJPUSNTGOMMGY-MRVIYFEKSA-N

Canonical SMILES: CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

Isomeric SMILES: C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

Synonyms: etoposide; VePesid; 33419-42-0; Toposar; trans-Etoposide; (-)-Etoposide; Lastet; Zuyeyidal; …

Botanical Source:

Product Overview

Etoposide, a semisynthetic derivative of podophyllotoxin, is provided by BIORLAB at pharmaceutical-grade purity (≥99%). This critical anticancer compound has established efficacy in cancer research, particularly for lung cancer and testicular cancer studies.

Technical Specifications

• Molecular Formula: C₂₉H₃₂O₁₃
• Molecular Weight: 588.6 g/mol
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in methanol, and ethanol; slightly soluble in water
• Purity: ≥99% (HPLC)
• Storage Temperature: -20°C

Key Research Applications

• Cancer Research
  • DNA topoisomerase II inhibition studies
  • Cell division mechanism investigation
  • Apoptosis pathway research
• Therapeutic Development
  • Small cell lung cancer studies
  • Testicular cancer research
  • Combination therapy investigations

Mechanism of Action

• Inhibits DNA topoisomerase II
• Induces DNA strand breaks
• Triggers cancer cell apoptosis
• Activates multiple molecular pathways

Storage & Handling

• Store at -20°C under inert gas
• Protect from light and moisture
• Available in research quantities
• Reconstituted solutions stable for 24 hours at 2-8°C

Quality Assurance

• Complete analytical documentation
• Comprehensive Certificate of Analysis
• Batch-specific purity data
• Meets international pharmaceutical standards

Research Significance

1. Cell Death Mechanisms

   • VDAC1 overexpression and oligomerization
   • Calpain-mediated processes
   • Pro-apoptotic protein release

2. Clinical Applications

   • Lung cancer treatment research
   • Combination therapy studies
   • Drug resistance investigations

3. Molecular Pathways

   • Mitochondrial processes
   • Apoptosis regulation
   • Cell cycle control

Research Focus Areas

• Cancer Biology

  • Cell cycle regulation
  • Apoptosis mechanisms
  • Drug resistance studies

• Drug Development

  • Novel formulations
  • Delivery systems
  • Combination strategies

Safety & Handling Considerations

• Cytotoxic compound
• Requires controlled environment
• Proper PPE essential
• Specialized disposal protocols

For detailed technical information or custom requirements, contact BIORLAB’s scientific team.

Note: This product is for research and development purposes only. Highly potent material requiring specialized handling.