Description

High-purity Dehydroabietic Acid, a naturally occurring diterpene resin acid found in conifers such as Pinus species (P. densiflora, P. sylvestris) and grand fir (Abies grandis), with demonstrated anti-aging and biological activities.

Technical Specifications

• Molecular Formula: C₂₀H₂₈O₂
• Molecular Weight: 300.4 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in organic solvents

IUPAC Name: (1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid

InChI: InChI=1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1

InChIKey: NFWKVWVWBFBAOV-MISYRCLQSA-N

Canonical SMILES: CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)C(=O)O)C

Isomeric SMILES: CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3CC2)(C)C(=O)O)C

Synonyms: DEHYDROABIETIC ACID; Dehydroabietate; 1740-19-8; Abieta-8,11,13-trien-18-oic acid; Abietic acid, dehydro-; (-)-Dehydroabietic acid; (+)-Dehydroabietic acid; 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-; …

Botanical Source:

Key Research Findings

1. Anti-aging Properties

   • Direct SIRT1 activator
   • Extends lifespan in C. elegans
   • Prevents lipofuscin accumulation
   • Inhibits collagen secretion in fibroblasts

2. Molecular Mechanisms

   • Directly binds to SIRT1 protein
   • Independent of NAD+ levels
   • Increases SIRT1 protein expression
   • Deacetylates PGC-1α

Research Applications

1. Anti-aging Research

   • Lifespan extension studies
   • SIRT1 activation analysis
   • Lipofuscin accumulation
   • Collagen secretion

2. Biological Activities

   • Antimicrobial studies
   • Antiulcer research
   • Cardiovascular investigations
   • Age-related disease research

Latest Research Impact

• First identified anti-aging properties
• Direct SIRT1 activation mechanism
• Potential use in age-related diseases
• Preventive aging applications

Storage & Handling

• Store at -20°C
• Protect from light
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Key Research Areas

1. Aging Studies

   • SIRT1 pathway analysis
   • Longevity research
   • Age-related diseases
   • Preventive strategies

2. Mechanism Investigation

   • Protein binding studies
   • Enzyme activation
   • Cellular aging
   • Molecular pathways

This premium-grade Dehydroabietic Acid is specifically designed for research institutions advancing anti-aging and therapeutic development.

For research and development purposes only. Not for human consumption or clinical use.