Description
Corylifol A, extracted from the seeds of *Psoralea corylifolia L*, is a phenolic compound known for its diverse biological activities. It inhibits IL-6-induced STAT3 promoter activity in Hep3B cells with an IC50 value of 0.81 ± 0.15 µM. Additionally, **Corylifol A** demonstrates dose-dependent inhibition of SARA PLpro, with IC50 values ranging between 4.2 and 38.4 µM. Furthermore, **Corylifol A** has been identified as a naturally occurring potent inhibitor of hCE2, exhibiting low Ki values ranging from 0.62 µM to 3.89 µM.
IUPAC Name: 3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one
InChI: InChI=1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+
InChIKey: ZBHUUXLHDOUMKM-REZTVBANSA-N
SMILES: CC(=CCC/C(=C/CC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)/C)C
Synonyms: Corylifol A; 775351-88-7; 3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one; 3-[3-[(2E)-3,7-DIMETHYL-2,6-OCTADIEN-1-YL]-4-HYDROXYPHENYL]-7-HYDROXY-4H-1-BENZOPYRAN-4-ONE; Corylifol A (Standard); CHEMBL4207318; SCHEMBL23028385; HY-N0897R; …
Botanical Source: Psoralea Fruit (Psoralea corylifolia)