Description
IUPAC Name: (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChIKey: VSJKWCGYPAHWDS-FQEVSTJZSA-N
Canonical SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
Isomeric SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
Synonyms: camptothecin; 7689-03-4; Camptothecine; (S)-(+)-Camptothecin; Campathecin; (+)-Camptothecin; (+)-Camptothecine; d-Camptothecin; …
Botanical Source: Camptotheca acuminata.
Product Overview
BIORLAB provides high-purity Camptothecin (≥98%), a potent topoisomerase I inhibitor isolated from Camptotheca acuminata. This compound is crucial for cancer research and DNA topology studies.
Technical Specifications
- Molecular Formula: C₂₀H₁₆N₂O₄
- Molecular Weight: 348.4 g/mol
- Appearance: Pale yellow crystalline powder
- Purity: ≥98% (HPLC)
- Melting Point: 264-267°C
- Solubility: DMSO, DMF
- Storage: -20°C, protected from light
Research Applications
Cancer Research
- TOP1 inhibition studies
- DNA damage research
- Apoptosis mechanisms
- Cell cycle studies
Key Research Areas
-
Molecular Studies
- DNA topology research
- Cell death pathways
- Drug resistance mechanisms
- Combination therapy studies
-
Drug Development
- Analog synthesis
- Structure-activity relationships
- Delivery systems
- Formulation research
Research Significance
-
Therapeutic Potential
- Anticancer activity
- TOP1 targeting
- DNA damage induction
- Cell cycle arrest
-
Biological Activities
- S-phase specific
- DNA cleavage
- Apoptosis induction
- Growth inhibition
Safety Considerations
- Highly potent compound
- Cytotoxic agent
- Requires proper containment
- Special disposal procedures
Storage & Handling
- Store at -20°C
- Protect from light
- Available in research quantities
- Stability data provided
- Special handling protocols required
Quality Assurance
- Full spectroscopic characterization
- Comprehensive Certificate of Analysis
- Batch-specific HPLC profiles
- Stability testing data
- Research-grade documentation
Product Features & Benefits
- Highest available purity
- Batch-to-batch consistency
- Comprehensive documentation
- Technical support available
- Custom packaging options
Target Applications
- Cancer research centers
- Drug development facilities
- Pharmaceutical R&D laboratories
- Academic research institutions
Technical Support Features
- Method development assistance
- Analytical testing guidance
- Stability data available
- Research protocol support
- Documentation assistance
For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.
WARNING: This compound is highly potent and cytotoxic. Handle with appropriate safety measures.