Description

IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

InChI: InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

InChIKey: BMQGVNUXMIRLCK-OAGWZNDDSA-N

Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

Synonyms: CABAZITAXEL; Jevtana; 183133-96-2; Taxoid XRP6258; Xrp6258; Cabazitaxelum; XRP-6258; kabazitaxel; …

Botanical Source: Taxus chinensis

Product Overview

BIORLAB provides pharmaceutical-grade Cabazitaxel (≥98%), a semisynthetic taxane derivative crucial for advanced cancer research. This highly pure compound supports cutting-edge oncology research and drug development programs.

Technical Specifications

• Molecular Formula: C₄₅H₅₇NO₁₄
• Molecular Weight: 835.9 g/mol
• Appearance: White to off-white crystalline powder
• Purity: ≥98% (HPLC)
• Solubility: Soluble in DMSO and ethanol
• Storage: -20°C
• Form: Crystalline powder

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Stability testing data
• Research-grade documentation

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Available in research quantities
• Stability data provided
• Special handling protocols available

Research Applications

Cancer Research

• Prostate cancer studies
• Drug resistance research
• Combination therapy investigations
• Mechanism of action studies

Therapeutic Development

• Novel formulation development
• Bioavailability studies
• Drug delivery systems
• Resistance mechanism research

Key Research Areas

1. Oncology Studies

   • Metastatic cancer research
   • Hormone-refractory studies
   • Resistance mechanisms
   • Combination therapies

2. Drug Development

   • Formulation optimization
   • Delivery system design
   • Stability enhancement
   • Bioavailability improvement

Product Features & Benefits

• Highest available purity
• Batch-to-batch consistency
• Comprehensive documentation
• Technical support available
• Custom packaging options

Target Applications

• Pharmaceutical R&D laboratories
• Oncology research centers
• Drug development facilities
• Academic research institutions

Technical Support Features

• Method development assistance
• Analytical testing guidance
• Stability data available
• Research protocol support
• Documentation assistance

Research Significance

1. Therapeutic Potential

   • Advanced prostate cancer
   • Multidrug resistance
   • Novel combination approaches
   • Treatment optimization

2. Biological Activities

   • Microtubule stabilization
   • Cell division inhibition
   • Apoptosis induction
   • Drug resistance management

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only. Not for human consumption or therapeutic use without proper approval.