Description

IUPAC Name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

InChI: InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1

InChIKey: QGJZLNKBHJESQX-FZFNOLFKSA-N

Canonical SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O

Isomeric SMILES: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O

Synonyms: betulinic acid; 472-15-1; Mairin; Betulic acid; Lupatic Acid; als-357; 3-Hydroxylup-20(29)-en-28-oic acid; 3beta-Hydroxy-20(29)-lupaene-28-oic acid; …

Botanical Source: Betula platyphylla Suk.

Product Overview

BIORLAB presents high-purity Betulinic Acid (BA), a naturally occurring pentacyclic triterpene with significant applications in cancer research and tumor therapy.

Technical Specifications

• Chemical Formula: C₃₀H₄₈O₃
• Source: Birch bark and other natural sources
• Purity: ≥98% (HPLC)
• Appearance: White crystalline powder
• Storage: -20°C, protected from light

Key Research Applications

Cancer Research

1. Anti-tumor Properties

   • Apoptosis induction
   • Tumor progression suppression
   • Cancer cell inhibition
   • Multiple pathway modulation

2. Molecular Mechanisms

   • PI3K/AKT signaling impact
   • SOS-mediated nucleotide exchange inhibition
   • K-RAS4B protein modulation
   • Cell cycle regulation

Research Significance

Recent Developments

1. Novel Derivatives

   • Monophthalate derivatives
   • Enhanced activity profiles
   • Improved targeting
   • Better solubility

2. Mechanism Insights

   • RAS-related cancer targeting
   • Molecular glue effect
   • K-RAS4Ballo: SOS complex stabilization
   • Novel mode of action

Research Value

1. Cancer Applications

   • Multiple cancer types
   • Various mechanisms
   • Drug development potential
   • Combination therapy studies

2. Therapeutic Potential

   • Natural product advantages
   • Cell-specific cytotoxicity
   • Selective activity
   • Multiple targets

Storage & Handling

• Store at -20°C
• Protect from light
• Available in research quantities
• Stability data provided

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Research-grade documentation

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only.