Description

IUPAC Name: 4-[(2E)-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one

InChI: InChI=1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+

InChIKey: DBMJZOMNXBSRED-OQLLNIDSSA-N

Canonical SMILES: CC(=CCCC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C)C

Isomeric SMILES: CC(=CCC/C(=C/COC1=C2C=CC(=O)OC2=CC3=C1C=CO3)/C)C

Synonyms: Bergamottin; 7380-40-7; Bergamotine; Bergaptin; 5-Geranoxypsoralen; Bergamotin; 5-Geranyloxypsoralen; Bergomottin; …

Botanical Source: Citrus limon (L.) Burm. f.

Product Overview

High-purity Bergamottin (5-Geranoxypsoralen), a natural furanocoumarin isolated from grapefruit and other citrus species, is manufactured to exceptional standards for drug metabolism and pharmaceutical research.

Technical Specifications

• Molecular Formula: C₂₁H₂₂O₄
• Molecular Weight: 338.40 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO, ethanol, and methanol; poorly soluble in water

Key Features & Benefits

• Natural CYP3A4 inhibitor
• Advanced purification technology
• Validated structure and activity
• Comprehensive Certificate of Analysis
• Full spectroscopic characterization

Research Applications

1. Drug Metabolism Studies

   • CYP450 inhibition research
   • Drug-drug interaction studies
   • Bioavailability enhancement
   • Metabolic pathway investigations

2. Pharmaceutical Development

   • Drug transport studies
   • P-glycoprotein interaction
   • Absorption enhancement research
   • Drug delivery optimization

3. Mechanism Studies

   • Enzyme inhibition kinetics
   • Structure-activity relationships
   • Metabolic profiling
   • Transport protein interactions

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Research Support

BIORLAB provides:

• Technical consultation
• Analytical method support
• Stability data
• Custom synthesis options
• Application Guidance

Key Research Areas

1. Drug Interactions

   • CYP3A4 inhibition mechanisms
   • Grapefruit juice effect studies
   • Drug bioavailability research
   • Metabolic interference studies

2. Absorption Enhancement

   • Intestinal permeability
   • Drug transport modulation
   • Bioavailability factors
   • Absorption mechanisms

3. Enzyme Kinetics

   • Inhibition constants
   • Time-dependent inhibition
   • Mechanism-based inactivation
   • Metabolic profiles

This premium-grade Bergamottin is specifically designed for research institutions and pharmaceutical companies advancing drug metabolism and interaction studies.

For research and development purposes only. Not for human consumption or clinical use.

[Contact BIORLAB’s technical support team for detailed specifications and custom requirements]