Description

IUPAC Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one

InChI: InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChIKey: BOJKULTULYSRAS-OTESTREVSA-N

Canonical SMILES: CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O

Isomeric SMILES: C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3[C@@H](COC3=O)O)(C)CO)O

Synonyms: Andrographolide; 5508-58-7; CHEBI:65408; HMPL004; UNII-410105JHGR; DTXSID3045980; 410105JHGR; EINECS 226-852-5; …

Botanical Source: Andrographis Herba

Product Overview

BIORLAB provides high-purity Andrographolide (≥98%), a bioactive labdane diterpenoid with significant applications in anti-inflammatory, anticancer, and metabolic research.

Technical Specifications

• Molecular Formula: C₂₀H₃₀O₅
• Molecular Weight: 350.4 g/mol
• Appearance: White crystalline powder
• Purity: ≥98% (HPLC)
• Solubility: DMSO, ethanol
• Storage: -20°C, protected from light

Research Applications

Primary Research Areas

• Anti-inflammatory studies
• Cancer research
• Metabolic investigations
• Drug development

Key Research Areas

1. Cancer Studies

   • Growth suppression
   • Cell propagation
   • Cancer cell relocation
   • Multiple pathways

2. Inflammatory Research

   • iNOS expression
   • Akt and JNK signaling
   • NF-κB activation
   • ROS generation

Research Significance

1. Biological Activities

   • Cancer cell suppression
   • Anti-inflammatory effects
   • Vascular protection
   • Multiple mechanisms

2. Molecular Targets

   • iNOS downregulation
   • NF-κB inhibition
   • ROS modulation
   • Signal cascade regulation

Research Value

• Promising therapeutic agent
• Inflammatory vascular diseases
• Drug development applications
• Multiple biological targets

Storage & Handling

• Store at -20°C
• Protect from light
• Available in research quantities
• Stability data provided
• Special handling protocols available

Quality Assurance

• Full spectroscopic characterization
• Comprehensive Certificate of Analysis
• Batch-specific HPLC profiles
• Stability testing data
• Research-grade documentation

Target Applications

• Cancer research centers
• Drug development facilities
• Inflammation research labs
• Academic institutions

For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.

Note: This product is intended for laboratory research purposes only.