Description
IUPAC Name: (1R,9R,10S,12R,13S,14R,16S,17S,18R)-13-ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol
InChI: InChI=1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11-,14-,15-,16-,17-,18+,19+,20+/m0/s1
InChIKey: CJDRUOGAGYHKKD-RQBLFBSQSA-N
Canonical SMILES: CCC1C2CC3C4C5(CC(C2C5O)N3C1O)C6=CC=CC=C6N4C
Isomeric SMILES: CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H]([C@H]2[C@H]5O)N3[C@@H]1O)C6=CC=CC=C6N4C
Synonyms: (+)-Ajmaline; 4360-12-7; Ajmalan-17,21-diol, (17R,21a)-; Ajmalin; Ajmaline; Cardiorythmine; Gilurytmal; Ignazin; …
Botanical Source: Rauvolfia verticillata
Product Overview
BIORLAB presents high-purity Ajmaline, a well-established antiarrhythmic agent derived from Rauwolfia serpentina, primarily used in cardiac arrhythmia research and Brugada syndrome diagnostics.
Technical Specifications
- Source: Rauwolfia serpentina
- Class: Class Ia antiarrhythmic drug
- Chemical Category: Monoterpenoid indole alkaloid (MIA)
- Purity: ≥98% (HPLC)
- Storage: -20°C, protected from light
Key Research Applications
Clinical Applications
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Cardiac Research
- Ventricular arrhythmias
- Brugada syndrome diagnosis
- Cardiac rhythm stabilization
- Sodium channel studies
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Mechanism Studies
- Nav1.5 Cardiac sodium channels
- Phase 0 depolarization
- Conduction velocity
- Ion channel interactions
Research Significance
Therapeutic Effects
-
Primary Actions
- Sodium channel blocking
- Cardiac rhythm stabilization
- Action potential modulation
- Reentrant arrhythmia management
-
Secondary Effects
- Potassium channel modulation
- Calcium channel interaction
- Action potential duration extension
- Refractory period modification
Storage & Handling
- Store at -20°C
- Protect from light
- Available in research quantities
- Stability data provided
Quality Assurance
- Full spectroscopic characterization
- Comprehensive Certificate of Analysis
- Batch-specific profiles
- Research-grade documentation
For detailed technical information, bulk quantities, or custom requirements, contact BIORLAB’s scientific team.
Note: This product is intended for laboratory research purposes only.