Description

IUPAC Name: (2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoic acid

InChI: InChI=1S/C12H14N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,13-14H,6H2,1H3,(H,15,16)/t11-/m0/s1

InChIKey: CZCIKBSVHDNIDH-NSHDSACASA-N

Canonical SMILES: CNC(CC1=CNC2=CC=CC=C21)C(=O)O

Isomeric SMILES: CN[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O

Synonyms: Abrine; L-Abrine; 526-31-8; N-Methyl-L-tryptophan; Nalpha-Methyl-L-tryptophan; N-Methyl-L-tryptophane; methyl-l-tryptophan; (2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoic acid; …

Botanical Source: Abrus precatorius

Product Overview

High-purity Abrine (N-methyl-L-tryptophan), a natural indole alkaloid isolated from Abrus precatorius, manufactured to exceptional standards for pharmaceutical research and biological studies.

Technical Specifications

• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.25 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO and methanol

Key Features & Benefits

• Natural amino acid derivative
• Anti-inflammatory properties
• Validated structure and activity
• Comprehensive Certificate of Analysis
• Full spectroscopic characterization

Research Applications

1. Osteoarthritis Research

   • Cell proliferation studies
   • Anti-apoptotic investigations
   • IL-1β stimulated pathways
   • Chondrocyte protection studies

2. Pharmaceutical Development

   • Anti-inflammatory research
   • Cell signaling studies
   • PIM2/VEGF pathway research
   • Drug discovery screening

3. Mechanism Studies

   • Cell signaling pathways
   • Molecular target identification
   • VEGF expression research
   • Growth factor modulation

Storage & Handling

• Store at the recommended temperature
• Protect from light and moisture
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Research Support

BIORLAB provides:

• Technical consultation
• Analytical method support
• Stability data
• Custom synthesis options
• Application Guidance

Key Research Areas

1. Joint Health Studies

   • Cartilage protection
   • Anti-inflammatory effects
   • Cell survival promotion
   • IL-1β pathway modulation

2. Cell Signaling Research

   • PIM2 expression studies
   • VEGF signaling pathways
   • p-VEGFR2 modulation
   • p-eNOS regulation

3. Therapeutic Development

   • OA treatment research
   • Anti-inflammatory applications
   • Cell protection mechanisms
   • Drug development studies

This premium-grade Abrine is specifically designed for research institutions and pharmaceutical companies advancing therapeutic development and scientific research.

For research and development purposes only. Not for human consumption or clinical use.

[Contact BIORLAB’s technical support team for detailed specifications and custom requirements]