Separation and Purification
Separation and Purification are important steps in obtaining high-quality natural compounds.
Purification Service
Purification stands as a critical juncture in the acquisition of high-caliber compounds. Taking active pharmaceutical ingredients (APIs) as an illustration, the methodologies favored to date for API purification encompass distillation, adsorption-desorption, solvent extraction, fractional crystallization, and chromatography. For intricate separations necessitating the elimination of trace contaminants, purification predominantly hinges on diverse crystallization or chromatographic techniques. BOC Sciences meticulously cultivates contract purification services tailored for high-value-added substances, inclusive of chemical pharmaceuticals.
Purification Products
Our extensive repository of separation and purification expertise empowers us to provide the following high-purity compounds:
- Active pharmaceutical ingredients (API)
- Peptides
- Oligonucleotides
- Chiral compounds
- Achiral compounds
- Impurities
- Specialty sugars
- Lipids
- Phospholipids
- Fatty acids
- Proteins
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Purification Custom Services
In alignment with client stipulations, we offer a comprehensive purification customization service encompassing the preparation and purification experiment, process design, to impurity enrichment/separation. We meticulously select the suitable process and equipment system predicated on process requirements and product characteristics.
Purification Service Process
- Active ingredient extraction: extraction equipment such as reflux extraction, ultrasonic extraction, supercritical extraction, and other extraction equipment is used to extract the active ingredients of drugs.
- Concentration: using a rotary evaporator, and vacuum concentration equipment to concentrate the extract.
- Separation and purification: Separation and purification are carried out using different types of separation equipment such as atmospheric pressure, medium pressure, high pressure, etc., and different separation materials such as forward, reverse, and MCI.
- Drying: According to the physical and chemical properties of natural drug ingredients, different drying methods such as vacuum, freezing, spraying, etc. are adopted for drying.
- Purity analysis: HPLC, GC, and other chromatographic techniques are used to analyze the purity of natural medicines.
- Structural identification: NMR, MS, and other techniques analyze the molecular structure.
Our Advantages
- Core patented high-efficiency separation materials; unique separation technology for saponin and alkaloid active ingredients.
- We refine methods based on objectives and desired purity, recommending efficient separation strategies to curtail costs.
- Our state-of-the-art equipment and standard laboratory are supervised, maintained, and operated by adept personnel.
- Satisfy the potential preparation application of various molecules in scientific research or pilot scale.
- Our optimized contract purifications consistently yield tangible results for our partners, we support our customers' research or production in the best possible way every time.
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FAQs
Purification is essential for obtaining high-quality compounds, such as active pharmaceutical ingredients (APIs). It ensures the removal of impurities and enhances the compound's efficacy and safety for use in various applications.
We utilize techniques such as liquid-solid chromatography (VLC, FC, MPLC, HPLC), ion-exchange chromatography, solid-phase extraction, crystallization, distillation, and freeze-drying.
The method is chosen based on the compound's properties, such as polarity, solubility, and stability. We often start with preliminary tests like thin-layer chromatography (TLC) and then scale up to more sophisticated techniques like HPLC or CPC.
Yes, we specialize in purifying compounds from complex mixtures, using advanced chromatographic techniques.
We typically achieve purity levels of >98% for isolated compounds, verified through analytical methods such as NMR and mass spectrometry.
Yes, BIORLAB provides comprehensive purification customization services. This includes preparation and purification experiments, process design, and impurity enrichment/separation. The suitable process and equipment are selected based on the specific requirements and characteristics of the product.
BIORLAB ensures quality and consistency through the use of advanced technologies, rigorous process controls, and continuous optimization. Our dedicated team of experts supervises every step to deliver reliable and reproducible results for our partners.
