Lovastatin is a naturally occurring compound belonging to the statin class of molecules. Originally isolated from Aspergillus terreus, this potent HMG-CoA reductase inhibitor has revolutionized cardiovascular disease treatment and research.

Technical Specifications

– Molecular Formula: C₂₄H₃₆O₅
– Molecular Weight: 404.5 g/mol
– CAS Number: 75330-75-5
– Appearance: White crystalline powder
– Purity: ≥98% (HPLC)
– Storage: -20°C under inert atmosphere

Key Applications

Pharmaceutical Research

– Cholesterol biosynthesis inhibition studies
– Cardiovascular disease research
– Drug development and formulation
– Mechanism of action investigations
– Structure-activity relationship studies

Therapeutic Potential

– Hypercholesterolemia treatment research
– Atherosclerosis prevention studies
– Cardiovascular risk reduction research
– Lipid metabolism investigations

Biological Activity

Lovastatin acts as a competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. This compound effectively reduces cholesterol production by:
– Blocking mevalonate pathway
– Decreasing LDL cholesterol levels
– Modulating lipid metabolism
– Exhibiting pleiotropic effects

Quality Assurance

BIORLAB’s Lovastatin meets rigorous quality standards:
– Validated analytical methods
– Comprehensive COA documentation
– Batch-to-batch consistency
– Full structural characterization

Research Applications

Ideal for various research applications:
– In vitro cellular studies
– Preclinical investigations
– Formulation development
– Bioavailability studies
– Stability testing

Handling and Safety

– Store at -20°C
– Protect from light and moisture
– Handle with appropriate safety measures
– Refer to SDS for detailed information

Contact BIORLAB’s technical support team for detailed specifications and custom requirements. Our expert staff provides comprehensive support for your research needs.