Description
IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChIKey: RCINICONZNJXQF-MZXODVADSA-N
Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Synonyms: 33069-62-4; P88XT4IS4D; Paclitaxel; Taxol; Taxol A; Yewtaxan; Genaxol; Plaxicel; …
Botanical Source: Taxus chinensis
Paclitaxel, a complex diterpenoid natural product originally isolated from the Pacific yew tree (Taxus brevifolia), represents one of the most significant advances in cancer therapeutics. BIORLAB offers high-purity paclitaxel (>98%) for pharmaceutical research and development applications.
Technical Specifications
– Molecular Formula: C₄₇H₅₁NO₁₄
– Molecular Weight: 853.9 g/mol
– CAS Number: 33069-62-4
– Appearance: White to off-white crystalline powder
– Solubility: Practically insoluble in water, highly soluble in organic solvents
– Storage: Store at -20°C, protected from light
Key Applications in Pharmaceutical Research
Cancer Treatment Development
– Potent microtubule-stabilizing agent
– Effective against various cancer types, including:
– Ovarian cancer
– Breast cancer
– Non-small cell lung cancer
– Pancreatic cancer
– Kaposi’s sarcoma
Mechanism of Action
Paclitaxel functions by:
– Binding to β-tubulin subunits
– Promoting microtubule assembly
– Preventing cell division
– Inducing apoptosis in cancer cells
Research & Development Applications
– Drug delivery system development
– Combination therapy studies
– Bioavailability enhancement research
– Novel formulation development
– Resistance mechanism studies
Quality Assurance
BIORLAB’s paclitaxel undergoes:
– Rigorous purity testing
– Comprehensive chemical analysis
– Strict quality control measures
– Full documentation and certification
Contact BIORLAB’s technical support team for detailed specifications, pricing, and custom requirements.