Description

High-purity Baccatin III, a critical taxane diterpenoid isolated from Taxus species, serving as the key precursor for semi-synthetic production of paclitaxel and other taxane-based anticancer drugs.

Technical Specifications

• Molecular Formula: C₃₁H₃₈O₁₁
• Molecular Weight: 586.6 g/mol
• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in chloroform, DMSO; sparingly soluble in methanol

IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-1,9,15-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

InChI: InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1

InChIKey: OVMSOCFBDVBLFW-VHLOTGQHSA-N

Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C

Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C

Synonyms: Baccatin III; 27548-93-2; BACCATINE III; CHEBI:32898; 40K5PZ0K67; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; [(1~{S},2~{S},3~{R},4~{S},7~{R},9~{S},10~{S},12~{R},15~{S})-4,12-diacetyloxy-10,14,16,16-tetramethyl-1,9,15-tris(oxidanyl)-11-oxidanylidene-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl] benzoate; NSC 330753; …

Botanical Source: Taxus chinensis

Key Features & Benefits

• Natural taxane precursor
• Semi-synthetic intermediate
• Validated structure and purity
• Comprehensive Certificate of Analysis
• Full spectroscopic characterization
• Complete traceability

Research Applications

1. Pharmaceutical Development

   • Paclitaxel synthesis
   • Taxane drug development
   • Process optimization
   • Scale-up studies

2. Synthetic Chemistry

   • Method development
   • Reaction optimization
   • Structure modification
   • SAR studies

3. Cancer Research

   • Anticancer drug development
   • Mechanism studies
   • Drug delivery systems
   • Combination therapy research

Storage & Handling

• Store at -20°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles
• Stock solution guidelines provided
• 24-month stability under recommended conditions

Quality Assurance

• GMP-compliant manufacturing
• Rigorous quality control
• Complete analytical documentation
• Traceable lot numbers
• Stability monitoring program

Package Sizes

• 5mg
• 10mg
• 25mg
• 100mg
• Bulk quantities available

Key Research Areas

1. Drug Development

   • Taxane synthesis
   • Process optimization
   • New derivative development
   • Scale-up methodology

2. Production Methods

   • Semi-synthetic routes
   • Green chemistry
   • Sustainable production
   • Yield optimization

Research Support

BIORLAB provides:

• Technical consultation
• Analytical method support
• Stability data
• Custom synthesis options
• Application Guidance

Current Applications

1. Pharmaceutical Industry

   • Drug precursor synthesis
   • Process development
   • Quality control
   • Method validation

2. Academic Research

   • Synthetic methodology
   • Mechanism studies
   • Structure modifications
   • Biology studies

This premium-grade Baccatin III is designed for research institutions and pharmaceutical companies advancing therapeutic development and drug manufacturing processes.

For research and development purposes only. Not for human consumption or clinical use.