Description

Decursin is a bioactive pyranocoumarin compound primarily isolated from the roots of Angelica gigas Nakai (Korean Angelica), a medicinal plant with significant importance in traditional East Asian medicine. BIORLAB offers high-purity decursin (≥98%) isolated through advanced extraction and purification technologies. This pharmacologically active coumarin derivative serves as a valuable research tool for pharmaceutical development, particularly in neurological, cardiovascular, and cancer research applications.

Technical Specifications

• Appearance: White to off-white crystalline powder
• Purity: ≥98% (HPLC)
• Melting Point: 115-117°C
• Optical Rotation: [α]D20 +80° (c 0.1, CHCl3)
• UV Absorption: λmax at 230, 330 nm in methanol
• Solubility: Soluble in DMSO, methanol, ethanol, acetone, chloroform; insoluble in water
• LogP: 3.84 (predicted)

IUPAC Name: [(3S)-2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g]chromen-3-yl] 3-methylbut-2-enoate

InChI: InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1

InChIKey: CUKSFECWKQBVED-INIZCTEOSA-N

Canonical SMILES: CC(=CC(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C)C

Isomeric SMILES: CC(=CC(=O)O[C@H]1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C)C

Synonyms: Decursin; 5928-25-6; (+)-Decursin; (S)-(+)-Decursin; UNII-E95RTO3YQR; E95RTO3YQR; C19H20O5; CHEBI:4353; …

Botanical Source: Angelicae sinensis Radix

Storage and Handling Requirements

• Store at -20°C in airtight containers
• Protect from light and moisture
• Allow container to reach room temperature before opening
• Stock solutions can be prepared in DMSO or ethanol (10 mg/ml recommended)
• Solutions should be stored at -20°C and protected from light
• Avoid repeated freeze-thaw cycles
• Stable for 24 months when properly stored
• Working solutions should be prepared fresh

Research Applications

Pharmaceutical Research

• Neuroprotective Studies: Demonstrates significant protection against neuronal damage and potential for neurodegenerative disease research
• Anticancer Investigations: Shows promising activity against various cancer cell lines through multiple mechanisms including cell cycle arrest, apoptosis induction, and anti-angiogenesis
• Cardiovascular Research: Exhibits vasorelaxant effects and potential for cardiovascular disease research
• Anti-inflammatory Studies: Demonstrates inhibitory effects on inflammatory mediators and pathways
• Antioxidant Research: Shows significant free radical scavenging activity and protection against oxidative stress

Biological Mechanism Research

• STAT3 Signaling Pathway Studies: Important for investigating cancer cell survival and proliferation mechanisms
• ERK/MAPK Pathway Research: Valuable for studying cell differentiation and growth regulation
• PI3K/Akt Signaling Investigations: Critical for understanding cell survival pathways
• Apoptosis Mechanism Studies: Essential for programmed cell death research
• Cell Cycle Regulation Research: Important for understanding cellular proliferation control

Traditional Medicine Validation

• East Asian Medicine Research: Valuable for scientific validation of traditional Korean and Chinese medicinal applications
• Natural Product Chemistry: Essential for standardization and quality control of Angelica gigas preparations
• Ethnopharmacological Studies: Important for understanding traditional medicinal practices from a modern scientific perspective
• Herbal Medicine Development: Critical for developing evidence-based herbal formulations

Biological Activities

• Anticancer Effects: Demonstrates cytotoxicity against various cancer cell lines with IC50 values ranging from 10-50 μM
• Neuroprotective Activity: Shows protection against neuronal damage in various neurotoxicity models
• Anti-inflammatory Properties: Inhibits expression of pro-inflammatory cytokines and mediators
• Antioxidant Capacity: Exhibits significant DPPH radical scavenging activity
• Memory Enhancement: Demonstrates improvement in memory-related behavioral tests in animal models
• Vasorelaxant Effects: Shows relaxation of precontracted vascular smooth muscle

Source and Extraction

• Primarily isolated from the roots of Angelica gigas Nakai (Korean Angelica)
• Also found in lower concentrations in other Angelica species
• Extracted using environmentally responsible solvent systems
• Purified through multi-stage chromatographic processes
• Structure confirmed through comprehensive spectroscopic analysis
• Standardized extraction protocols ensuring batch consistency

Quality Assurance

BIORLAB’s decursin undergoes:

• Comprehensive HPLC analysis for purity determination (≥98%)
• Structure verification by 1H and 13C NMR spectroscopy
• Mass spectrometry confirmation
• UV-Vis spectral characterization
• Stereochemical configuration confirmation
• Water content analysis
• Residual solvent screening
• Microbial contamination testing
• Certificate of Analysis with batch-specific data

Research Value

• Reference Standard: Important for analytical method development and phytochemical profiling
• Lead Compound: Valuable scaffold for structure-activity relationship studies and drug development
• Biomarker: Essential for quality control of Angelica gigas extracts
• Biological Probe: Useful tool for investigating specific cellular mechanisms and pathways

Technical Support Services

• Method development assistance
• Analytical reference standard
• Custom purification options
• Bulk quantities available
• Technical consultation

For research use only. Not for human consumption or clinical use. All BIORLAB natural compounds are intended solely for laboratory research applications.

For detailed specifications, bulk quantities, or technical support, please contact BIORLAB’s scientific team.